Honestly that combination should run almost stock. The big valve heads will not make a huge difference. First thing I would do is find some compression. You can either find a new set of pistons that would bring you to about 10 to 1 or mill the heads but the stock compression ratio is too low. If you replace the pistons I would put in forged. Putting a bigger cam in there will make it worse with the low compression. After you get your compression up, I would put a larger cam. Something in .450 to .500 lift range. Something like the comp camse xtreme energy cam http://http://www.compcams.com/Compa...?csid=629&sb=2
You will have to make sure you check your piston to valve clearance and make sure you get the correct valve springs to go with it.
I would also put a windage tray in the engine.
Definately the big valve heads will work good then. You can have them ported for more power but not completely needed at this power level.
I would use a single plane Edelbrock victor or a performer RPM intake manifold. Carb should be around 650 to 750. Install a 3000 RPM converter and at least a 3.9 to 1 gear ratio in the rear. A shift kit or reverse valve body would be a good mod also.
If you can hook up you will run high 12s with this combo. I would rather run this combo than a 408 stroker.