OK here is an update, replaced the distributor, new intake gasket, carb gasket, timing set to factory specks. car is getting fuel. still runs rough. seems to be missing on two cylinders. plug wires are new as well as the coil, not sure what it could be? any ideas?
65 Chrysler 300
stock 383
factory air

 

300 -

Points or electronic? Probably points, I guess they were adjusted correctly.

Does it seem to be missing all the time, on idle or under load?

Are you sure the firing order is correct, and the distributor set to TDC on #1 (or whatever advance you used)?

Could the wires be arcing somewhere?

Can you confirm the misses by looking at the spark plug(s)?

Guess you already checked compression etc?

Archer

 

You can do a quick "load test" or "cylinder balance test"

Best to have a tach,

If you have a small sharp probe, like on a 12V test lamp, that will do. If not, take some small brads or finish nails, pull up the dist. cap boots, and gently push the brads down beside each plug wire.

Now run the car at "best idle" maybe a little fast, and use a clip lead to ground each brad one at a time. Each cylinder should drop the same RPM and 'sound' about the same as the others.

I'd bet you'll find one or two different.

Now you can switch plugs, wires, etc, check compression, and see if you can determine what's up with the one or two holes

 

Yea, I gotta tell ya due to recent experience I'm on board with the compression test, first thing!

Joe.